Purine nucleosides
Apexbio Technology LLC 2'-Deoxyguanosine 961-07-9 1g
2 -Deoxyguanosine (CAS 961-07-9) is a purine deoxyribonucleoside comprising guanine coupled to a deoxyribose moiety As an essential constituent of DNA it serves as a substrate in multiple nucleotide metabolism pathways Its interconversion with 2 -deoxyguanosine 5 -monophosphate is mediated by purine 5 -nucleotidase and deoxyguanosine kinase reflecting its role in nucleic acid turnover In biomedical research 2 -deoxyguanosine is utilized to study DNA synthesis repair mechanisms and enzymatic processes involving nucleoside metabolism Altered deoxyguanosine homeostasis has been implicated in purine nucleoside phosphorylase deficiency underscoring its significance in inherited metabolic disorders
Medchemexpress LLC 2'-Deoxyadenosine monohydrate-13C10,15N5 hydrate | 2483830-27-7 | 99.7% | 284.15 | 5 MG
2'-Deoxyadenosine monohydrate-13C10,15N5 is the 13C and 15N labeled 2'-Deoxyadenosine monohydrate. 2'-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. It also inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. It activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH) and the growth of various cells. It has an anticancer effect on colon cancer.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Guanosine, 8-bromo-2'-deoxy- | 13389-03-2 | ≥98.0% | 346.14 | 1 ML
8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and early biomarker of oxidative tissue damage. It serves as an immunogen for mAb8B3, detecting DNA modifications. Elevated urinary levels occur in inflammatory disease models. Used in studies for inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation.
- Inflammation-related DNA halogenated adduct.
- Early biomarker of inflammation-induced oxidative tissue damage.
- Immunogen for mAb8B3 monoclonal antibody.
- Urinary levels increase in inflammatory disease models.
- Applications in inflammatory diseases, diabetes, hepatocellular carcinoma, UV-B induced skin inflammation.
- High, specific cross-reactivity with mAb8B3 in competitive indirect ELISA.
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | 99.9% | 269.26 | 1 ML
2'-Deoxyadenosine monohydrate is an adenine nucleoside used in research that demonstrates various biological activities including the inhibition of glucose-stimulated insulin release and islet cAMP accumulation. It also activates caspase-3, promotes apoptosis, inhibits SAHH activity, and has an anticancer effect on colon cancer by inhibiting cell growth.
- Inhibits glucose-stimulated insulin release.
- Inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation.
- Activates caspase-3 and promotes apoptosis.
- Inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH).
- Inhibits the growth of various cells.
- Has an anticancer effect on colon cancer.
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | 99.9% | 269.26 | 10 G
2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release and glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation. It activates caspase-3 and promotes apoptosis, and inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). This compound can inhibit the growth of various cells and has an anticancer effect on colon cancer.
- Inhibits glucose-stimulated insulin release
- Activates caspase-3 and promotes apoptosis
- Inhibits S-adenosyl-L-homocysteine hydrolase (SAHH) activity
- Inhibits the growth of various cells
- Demonstrates an anticancer effect on colon cancer
- For research use only
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | MFCD00149364 | >99.8% | 269.26 | 100 G
2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. It also inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation, activates caspase-3, and promotes apoptosis. Additionally, it inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH) and the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer. It is for research use only and not sold to patients.
- Inhibits glucose-stimulated insulin release.
- Inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation.
- Activates caspase-3.
- Promotes apoptosis.
- Inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH).
- Inhibits the growth of various cells.
- Has an anticancer effect on colon cancer.
Medchemexpress LLC N6-Isopentenyladenosine | 7724-76-7 | 99.4% | 335.36 | 1 ML
N6-Isopentenyladenosine (Riboprine) is an RNA modification found in cytokinins, which are known to regulate plant growth and differentiation. It is also present in a subset of tRNAs, where it enhances the efficiency and accuracy of translation. This compound is an end product of the mevalonate pathway and functions as an autophagy inhibitor, demonstrating interesting anti-melanoma activity.
- RNA modification found in cytokinins
- Regulates plant growth/differentiation
- Improves efficiency and accuracy of translation in tRNAs
- End product of the mevalonate pathway
- Autophagy inhibitor
- Exhibits anti-melanoma activity
Medchemexpress LLC 5'-Deoxyadenosine | 4754-39-6 | 99.9% | 251.24 | 10 MG
5'-Deoxyadenosine is an oxidized nucleoside found in the urine of normal subjects. It demonstrates anti-orthopoxvirus activity.
- Oxidized nucleoside
- Found in the urine of normal subjects
- Shows anti-orthopoxvirus activity
- For research use only
Biotium MUC1 / CA15-3 / EMA / CD227 (Epithelial Marker)(VU-4H5), CF740 conjugate, 0.1mg/mL
MAb VU-4H5 reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of MAb VU4H5 is APDTR as established with 'epitope fingerprinting'. VU-4H5 preferentially binds to under-glycosylated 'tumor' MUC1. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is upregulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Medchemexpress LLC 2'-Deoxyguanosine 5'-monophosphate disodium hydrate | 146877-98-7 | 99.0% | C10H14N5O7.H2O.2Na | 50 MG
2'-Deoxyguanosine 5'-monophosphate (dGMP) disodium hydrate is an oxidizable target of pterin (PT) used to evaluate the photosensitizing properties of biopterins. Pterin induces a photosensitive reaction of dGMP under UV-A radiation, leading to DNA damage via two primary mechanisms: electron transfer (type I) and singlet molecular oxygen production (type II).
- Oxidizable target of pterin (PT).
- Evaluates photosensitizing properties of biopterins.
- Induces DNA damage under UV-A radiation.
- Functions through Type I (electron transfer) and Type II (singlet molecular oxygen production) mechanisms.
- Relevant to cell cycle and DNA damage studies.
- Involved in DNA/RNA synthesis research.
Medchemexpress LLC 2'-deoxyadenosine-5'-monophosphate | 653-63-4 | 99.2% | 331.22 | C10H14N5O6P | 25 MG
2'-Deoxyadenosine-5'-monophosphate (dAMP) is a deoxyribonucleotide used as an analytical standard and reference material for nucleic acid research, method validation, and chromatographic or mass-spectrometry assays. Supplied as a solid in amber glass packaging, it is intended for calibration, quantitation, and analytical method development.
- High purity analytical standard suitable for HPLC and MS.
- Purity confirmed by HPLC (99.15% reported by COA).
- Molecular formula C10H14N5O6P and molecular weight 331.22.
- Supplied in brown glass to protect from light and moisture.
- Intended for calibration, method validation, and quantitative analyses.
Medchemexpress LLC 3'-deoxyguanosine | 3608-58-0 | 97.0% | 267.25 | 1 ML
3'-deoxyguanosine | 3608-58-0 | 97.0% | 267.25 | 1 ML
Medchemexpress LLC 3′-Deoxyguanosine | 3608-58-0 | 97.0% | 267.25 | 50 MG
3′-Deoxyguanosine | 3608-58-0 | 97.0% | 267.25 | 50 MG