Purine nucleosides
Medchemexpress LLC 6-Thio-2'-Deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 25 MG
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. This product is for research use only and not for sale to patients.
- Treatment results in rapid cell death for the vast majority of cancer cell lines tested, with IC50s between 0.7-2.9 μM.
- In A549 lung cancer cell-based mouse xenograft studies, it causes a decrease of the tumor growth rate, superior to that observed with 6-thioguanine treatment.
- It increases telomere dysfunction in tumor cells in vivo.
Medchemexpress LLC 2'-Deoxyguanosine | 961-07-9 | 99.9% | 267.25 | 10 G
2'-Deoxyguanosine is a purine nucleoside with diverse biological activities, known to induce DNA division in mouse thymus cells and act as a potent cell division inhibitor in plant cells. It also demonstrates inhibitory effects on the clonal growth of HL-60 and K562 leukemia cells, with observed IC50 values of 50 and 80 μM, respectively. This compound typically appears as a solid, ranging from white to off-white in color.
- Endogenous metabolite
- Harmful if swallowed
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
Medchemexpress LLC 2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 (dilithium) | 1927-31-7 | 99.2% | 517.94 | 1 MG
2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 (dATP-13C10,15N5) dilithium is a 13C and 15N-labeled nucleotide essential for DNA synthesis as a substrate of DNA polymerase. It is valuable in research as:
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC 2'-Deoxyadenosine-5'-triphosphate-13C10 dilithium | 1927-31-7 | 95.0% | 512.97 | 1 MG
2'-Deoxyadenosine-5'-triphosphate-13C10 dilithium (dATP-13C10 dilithium) is a 13C-labeled version of 2'-Deoxyadenosine-5'-triphosphate (dATP). dATP is a nucleotide crucial for DNA synthesis or replication in cells, serving as a substrate for DNA polymerase.
- Used as a tracer
- Used as an internal standard for quantitative analysis
- Suitable for analysis by NMR
- Suitable for analysis by GC-MS
- Suitable for analysis by LC-MS
Medchemexpress LLC Malvidin-3-O-arabinoside chloride | 28500-04-1 | 97.1% | 498.86 | 5 MG
Malvidin-3-O-arabinoside chloride (M3A chloride) is a research chemical that ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. It is used in studies to understand cellular processes related to oxidative stress and autophagy.
- Stimulates phosphorylation of AMP-activated protein kinase (AMPK)
- Upregulates LAMP-1 expression
- Restores lysosomal acidity and strengthens lysosomal functions
- Inhibits excess reactive oxygen species (ROS) generation
- Enhances glutathione (GSH) levels and autophagy flux
- Upregulates LC3-II/LC3-I ratio
Cayman Chemical N6-benzoyl-2-DeoxyadenosIn 1g
A nucleoside building block; has been used in the synthesis of various oligonucleotides
Medchemexpress LLC 2'-deoxyguanosine-13C monohydrate | 478511-26-1 | MFCD00080300 | 99.9% | 286.25 g/mol | C9(13)CH15N5O5 | 10 MG
2'-Deoxyguanosine-13C monohydrate is the carbon-13 isotopically labeled form of 2'-deoxyguanosine provided as the monohydrate solid for analytical and research applications, including metabolic flux analysis and isotope-tracing studies. The material is supplied with documentation (COA, SDS) and is intended for research use only.
- 13C labeled 2'-deoxyguanosine.
- Monohydrate solid form.
- Purity: 99.9% (HPLC).
- Molecular weight: 286.25 g/mol.
- Chemical formula: C9(13)CH15N5O5.
- CAS number: 478511-26-1.
- Typical pack size: 10 mg.
- Documentation available: COA and SDS for handling and storage.
- For research use only; not for human use.
Cayman Chemical 2-DeoxyadenosIn-5-monphos 1g
A derivative of AMP that has been used in the synthesis of novel photoaffinity labels for incorporation into DNA and to study adenosine-based interactions during DNA synthesis and DNA damage
Medchemexpress LLC Peonidin-3-O-arabinoside chloride | 524943-91-7 | 98.5% | 468.84 | 10 MG
Peonidin-3-O-arabinoside chloride is an anthocyanin that can be isolated from Vaccinium myrtillus L. This product is for research use only.
- For research use only
- Store at 4°C, sealed, away from moisture
- Stable in solvent for 6 months at -80°C or 1 month at -20°C
- Appearance: Solid, brown to black
- Molecular formula: C21H21ClO10
- Structure classification: Phenols, polyphenols
Medchemexpress LLC Peonidin-3-O-arabinoside chloride | 524943-91-7 | 98.5% | 468.84 | 25 MG
Peonidin-3-O-arabinoside chloride is an anthocyanin that can be isolated from *Vaccinium myrtillus L.*. This chemical compound is available as a solid with high purity, suitable for various research applications.
- High purity: 98.5%
- Solid appearance
- Brown to black color
- Recommended storage at 4°C, sealed, away from moisture
- Extended storage in solvent at -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC 8-Bromo-2'-deoxyadenosine | 14985-44-5 | ≥98.0% | 330.14 | 100 MG
8-Bromo-2'-deoxyadenosine is a purine nucleoside analog. These analogs possess broad antitumor activity against indolent lymphoid malignancies. Their anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis.
- Purine nucleoside analog
- Broad antitumor activity
- Inhibits DNA synthesis
- Induces apoptosis
Apexbio Technology LLC 6-O-Propynyl-2-deoxyguanosine 1mL(10 mM in DMSO)
6-O-Propynyl-2-deoxyguanosine (CAS 1640051-47-3) is a modified nucleoside featuring an alkyne functional group at the 6-position of deoxyguanosine This structural modification enables its use in bioorthogonal click chemistry reactions facilitating site-specific labeling and conjugation in nucleic acid research The alkynyl group serves as a chemical handle for copper-catalyzed azide-alkyne cycloaddition allowing researchers to attach probes or other functional molecules 6-O-Propynyl-2-deoxyguanosine is utilized for studying DNA structure dynamics and for the development of modified oligonucleotides in biochemical and molecular biology assays
Medchemexpress LLC 2'-deoxyadenosine-5'-monophosphate-d12 dilithium | 97.7% | 355.16 | C10D12Li2N5O6P | 1 MG
2'-Deoxyadenosine-5'-monophosphate-d12 (dilithium) is a deuterium-labeled form of 2'-deoxyadenosine-5'-monophosphate used as a research reagent to study DNA synthesis, nucleotide interactions, and isotope tracing by mass spectrometry or NMR. Supplied as the dilithium salt, it is intended for laboratory research use only.
- Isotopically labeled d12 for accurate mass-shift studies.
- Suitable for mass spectrometry and NMR applications.
- Dilithium salt form for improved solubility in selected buffers.
- High purity (97.7%) for reproducible experimental results.
- Compatible with nucleotide chemistry and DNA interaction studies.